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(154th Annual Meeting of the American Psychiatric Association) Pooled data from eight active-controlled clinical trials conducted in the United States, Europe and Canada involving 2,046 patients with moderate-to-severe depression indicate that during an eight-week period, patients taking extended-release venlafaxine (Effexor XR) experienced 18. 8 depression-free days (DFDs), those taking a selective serotonin reuptake inhibitor (SSRI) had 13. 6 DFDs and those receiving placebo had 7. 4 DFDs (based on a difference between median scores). Compared with placebo, venlafaxine and the SSRIs (paroxetine [Paxil], fluoxetine [Prozac] or fluvoxamine [Luvox]) were associated with sustained low rating on the Clinical Global Impressions-Severity of Illness (CGI-SI) scale as well. The 17-item Hamilton Rating Scale for Depression (HAM-17) was used to estimate the DFDs; this instrument, along with the CGI-SI, was used at baseline and then weekly during the eight-week period, and cumulative DFDs were compared across treatment groups. trusted online casinos dell mini pci slot slot back grand online guaranteed free casino bonus
